Substituted quinoline compound, and preparation method, medicine combination and application thereof

一种取代喹啉类化合物及其制备方法、药物组合物和应用

Abstract

The invention discloses a substituted quinoline compound represented as formula (I) and a medically acceptable substituted quinoline compound salt, a preparation method of the substituted quinoline compound, a medicine combination containing the substituted quinoline compound, and application of the substituted quinoline compound serving as a detection object in detecting in-vivo metabolism conditions of a substituted quinoline compound represented as formula (II), or application of the substituted quinoline compound in preparing HMG CoA reductase inhibitors or medicines which can effectively control or treat diseases by restraining HMG CoA reductase. The substituted quinoline compound represented as formula (I) is first found to be an in-vivo metabolite of a blood-fat-reducing compound represented as the formula (II), has good effect of inhibiting activity of the HMG CoA reductase, can be used for detecting the in-vivo metabolism conditions of the blood-fat-reducing compound represented as the formula (II), and is applied to treatment for diseases related to the HMG CoA reductase, such as hypercholesterolemia and atherosclerosis.
本发明公开了一种式I所示的取代喹啉类化合物或其药学上可接受的盐,及其制备方法和含其的药物组合物,以及其作为检测物在检测式II所示的取代喹啉类化合物体内代谢情况中的应用,或其在制备HMG CoA还原酶抑制剂,或预防或治疗通过抑制HMG CoA还原酶能有效防治的疾病的药物中的应用。本发明首次发现式I所示的取代喹啉类化合物为式II所示的降血脂化合物的体内代谢物,并发现其具有良好的HMG CoA还原酶活性抑制作用,可应用于检测式II所示的降血脂化合物的体内代谢情况,并应用于与HMG CoA还原酶相关类疾病,如高胆固醇血症、动脉粥样硬化性疾病方面的治疗。

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