Triterpenoid saponin compound extracted from clematis tangutica and application thereof

从甘青铁线莲中提取的三萜皂苷类化合物及用途

Abstract

本发明提供了一种从甘青铁线莲中提取的三萜皂苷类化合物,分子式为C59H96O27,采用高分辨质谱和二维核磁共振谱等光谱技术,以及化学方法,确定该化合物的化学结构为3β-O-[3-O-α-L-吡喃鼠李糖-(1→2)-α-L-吡喃阿拉伯糖]-21α-羟基-常春藤-28-O-α-L-吡喃鼠李糖-(1→4)-β-D-吡喃葡萄糖-(1→6)-β-D-吡喃葡萄糖(21α-hydroxy-3β-O-[3-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranosyl]-hederagenin-28-O-α-L-rhamnopyranosyl-(1→4)-β-D-glucopyranosyl-(1→6)-β-D-glucopyranoside)。体外抗心肌缺血活性结果显示,该化合物对缺氧/复氧模型诱导的心肌细胞损伤有明显的保护作用。本发明为治疗心肌缺血性疾病提供了先导化合物,可以成为新的心血管药物。
The invention provides a triterpenoid saponin compound extracted from clematis tangutica. The molecular formula of the triterpenoid saponin compound is C59H96O27. The chemical structure of the compound is determined as 3beta-O-[3-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyranoside]-21alpha-hydroxy-Chinese ivy-28-O-alpha-L-rhamnopyranosyl-(1->4)-beta-D-glucopyranose-(1->6)-beta-D-glucopyranose(21alpha-dydroxy-3beta-O-[3-O-alpha-L-rhamnopyranosyl-(1->2)-alpha-L-arabinopyran osyl]-hederagenin-28-O-alpha-L-rhamnopyranosyl-(1->4)-beta-D-glucopyranosyl-(1->6)-beta-D-glucopyranoside) by adopting spectrum technologies such as a high-resolution mass spectrum, a two-dimensional nuclear magnetic resonance spectrum and the like and a chemical method. As proved by an in-vitro anti-myocardial ischemia active result, the compound plays a remarkable role in protecting myocardial injury induced by an anoxic/reoxygenation model. The invention provides a lead compound for treating myocardial ischemia diseases, and the triterpenoid saponin compound can become a cardiovascular medicament.

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