Procedes pour produire de la pioglitazone et composes issus de ces procedes

Processes for making pioglitazone and compounds of the processes

Abstract

Pioglitazone can be made via a Darzens Condensation reaction in an industrially useful process.
Selon la présente invention, on peut produire de la pioglitazone au moyen d'une réaction de condensation de Darzens dans le cadre d'un processus industriel.

Claims

Description

Topics

Download Full PDF Version (Non-Commercial Use)

Patent Citations (4)

    Publication numberPublication dateAssigneeTitle
    EP-0008203-A1February 20, 1980Takeda Chemical Industries, Ltd.Thiazolidine derivatives, preparing same and pharmaceutical compositions comprising same
    EP-0193256-A1September 03, 1986Takeda Chemical Industries, Ltd.Thiazolidinedione derivatives, their production and use
    WO-02088120-A1November 07, 2002Léciva, a.s.Method for obtaining pioglitazone as an antidiabetic agent
    WO-03059864-A2July 24, 2003Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.Derives d'acide pheny(alkyl)carboxylique et derives phenylalkylheterocycliques dioniques et leur utilisation comme medicaments a activite d'abaissement de niveau de glucose serique et/ou lipides seriques

NO-Patent Citations (4)

    Title
    MOMOSE Y ET AL: "STUDIES ON ANTIDIABETIC AGENTS. X. SYNTHESIS AND BIOLOGICAL ACTIVITIES OF PIOGLITAZONE AND RELATED COMPOUNDS" CHEMICAL AND PHARMACEUTICAL BULLETIN, PHARMACEUTICAL SOCIETY OF JAPAN, TOKYO, JP, vol. 39, no. 6, June 1991 (1991-06), pages 1440-1445, XP000986045 ISSN: 0009-2363
    PATENT ABSTRACTS OF JAPAN vol. 017, no. 426 (C-1094), 9 August 1993 (1993-08-09) & JP 05 092972 A (TAKEDA CHEM IND LTD), 16 April 1993 (1993-04-16)
    PATENT ABSTRACTS OF JAPAN vol. 1997, no. 05, 30 May 1997 (1997-05-30) & JP 09 025273 A (NITTO CHEM IND CO LTD), 28 January 1997 (1997-01-28)
    RONGSHI LI, PATRICK S. FARMER, MEI XIE, MICHAEL A. QUILLIAM, STEPHAN PLEASANCE, SUSAN E. HOWLETT, POLLEN K.F. YEUNG: "Synthesis, Characterization, and Ca2+ Antagonistic Activity of Diltiazem Metabolites" J. MED. CHEM., vol. 35, 1992, pages 3246-3253, XP002333291

Cited By (2)

    Publication numberPublication dateAssigneeTitle
    CN-103980120-AAugust 13, 2014西北大学, 西安石油大学一种混旋丹参素异丙酯的合成方法
    WO-2012177956-A1December 27, 2012Metabolic Solutions Development Comapny, LlcPpar-sparing compounds for use in the treatment of diabetes and other metabolic diseases