Compositions et méthodes pour l'imagerie du cancer

Compositions and methods for imaging cancer

Abstract

La présente invention concerne des composés dérivés de la somatostatine de formule générale (I) qui peuvent être facilement marqués avec l'isotope 18 du fluor et qui présente une affinité et une sélectivité pour les récepteurs cellulaires de la somatostatine. Les composés marqués sont utiles cliniquement comme traceurs radioactifs dans diverses applications d'imagerie in vivo (par exemple, à l'aide d'une tomographie par émission de positons (PET) et de techniques associées) pour détecter des cellules et des tissus exprimant la somatostatine, notamment des tumeurs, ou comme agents thérapeutiques.
Somatostatin derivative compounds of general formula (I) that may be readily labelled with the isotope fluorine- 18 and that have affinity and selectivity for cellular somatostatin receptors are provided. The labelled compounds are useful clinically as radioactive tracers in various in vivo imaging applications (for example, using positron emission tomography (PET) and related techniques) to detect somatostatin-expressing cells and tissues, including tumours, or as therapeutic agents.

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Cited By (3)

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    WO-2016061142-A1April 21, 2016Novartis Ag, Dana-Farber Cancer Institute, Inc., President And Fellows Of Harvard CollegeAntibody molecules to pd-l1 and uses thereof
    WO-2016176572-A1November 03, 2016The United States Of America, As Represented By The Secretary, Department Of Health And Human ServicesMimétiques organotrifluoroborate d'acides aminés et leurs utilisations
    WO-2017117687-A1July 13, 2017British Columbia Cancer Agency Branch, The University Of British ColumbiaComposés marqués au 18/19f qui ciblent l'antigène membranaire spécifique de la prostate